TECNonix Bioreactor/Fermenter

Description

Fermenter geometry 3:1 Fermenter head without sharp edges to improve cleaning, GMP gasket Fermenter head with TC connections of various sizes (3/4, ½, 1), use them for additions, feeding, inoculation, etc. Working volume for 36L bioreactor: 20L, minimum working volume 7.5L (positioning holder for probes) Working volume for 74L bioreactor: 50L, dependent on position of last impeller Operational pressure range: -0.01 to 3.00 bar g Double mechanical seal Motor position: overhead motor shaft, as close as possible to sparger and bottom Impellers 3 Rushton / 3 Pitched Blade Configurable motor speed 50-1500 rpm Toroidal sparger with possibility of coupling and uncoupling Exhaust gas condenser Integrated CIP system Exhaust gas management: double exhaust gas line after the outlet filter (the gas line must divide into two branches: one direct to the spent gas analysis system (airnova) and the other to the drain/waste) Aeration 0 to 2. 5 VVM Inlet air from above and from the sparger, with flowmeter O2 inlet: 0 to 2.5 VVM, O2 inlet from above and from the sparger, with flowmeter N2 inlet: 0 to 1 VVM, N2 inlet from above and from the sparger, with flowmeter CO2 inlet 0 to 1 VVM, CO2 inlet from above and from the sparger, with flowmeter Head pressure adjustment: automatic Fixed speed pump with remote control Variable speed pumps, two bottom valves Bottom valve filter Integrity test: integrated housing to perform in situ integrity test Loading soil hole for manual loading Fixed speed Peristaltic pumping, position adjacent to bioreactor pH, for control of acid/ base, CO2 Feeding base inlet via Sacova valve with ingold control Utilities needed to run: Electrical requirements: 380v, 50Hz Steam feed: 3 - 9 bar Clean steam: 3 bar g Purified water Compressed air 8 bar g Nitrogen: 8 bar Refrigerated water: 9 - 12 deg C Oxygen: 12 bar CO2: 8 bar Softened water Drainage and discharge This fermenter/bioreactor has two distinct agitation systems, one high shear and one low shear, with different impellor set ups. This allows for high turbidity and low turbidity applications, dependent on the application and organism being grown in the fermentation process. The unit has the ability to run multiple types of organisms singularly from a minimum fermentation volume of 7.5L to a maximum of 75L however, the unit can run district volumes in between with the break point at 20L 30L giving the operator great flexibility. The control software on this machine is TIA Portal which was introduced to the public in 2010 and according to Siemens it will be supported for 22 years and parts will be available for another 5 years after that. SIEMENS TIA is back words compatible. The machine is using a Siemens S7-300 PLC and Ilinox Asem MH215 HMI Box of manuals included